Serial Bronchoalveolar Lavage Fluid Aspergillus Galactomannan and Treatment Response in Invasive Pulmonary Aspergillosis

Author:

Friedman Daniel Z P12,Theel Elitza S3,Walker Randall C1,Vikram Holenarasipur R4,Razonable Raymund R15,Vergidis Paschalis15ORCID

Affiliation:

1. Section of Infectious Disease, Department of Medicine, Mayo Clinic , Rochester, Minnesota , USA

2. Section of Infectious Diseases and Public Health, University of Chicago , Chicago, Illinois , USA

3. Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, Minnesota , USA

4. Division of Infectious Diseases, Mayo Clinic , Phoenix, Arizona , USA

5. William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic , Rochester, Minnesota , USA

Abstract

Abstract We studied patients diagnosed with aspergillosis based on positive bronchoalveolar lavage (BAL) Aspergillus galactomannan (GM) who had follow-up BAL sampling within 180 days. GM trend and clinical outcome were concordant in only 60% (30/50). While useful for the initial diagnosis, BAL GM trending does not always correlate with treatment response.

Publisher

Oxford University Press (OUP)

Reference12 articles.

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2. Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis;Pfeiffer;Clin Infect Dis,2006

3. Prognostic features of galactomannan antigenemia in galactomannan-positive invasive aspergillosis;Koo;J Clin Microbiol,2010

4. Correlation between circulating fungal biomarkers and clinical outcome in invasive aspergillosis;Neofytos;PLoS One,2015

5. Galactomannan detection in broncho-alveolar lavage fluid for invasive aspergillosis in immunocompromised patients;de Heer;Cochrane Database Syst Rev,2019

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