Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis-Reference-Cited by-同舟云学术

Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

Published:2021-02-05 Issue:4 Volume:8 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Molloy Síle F¹²,Ross Brad¹,Kanyama Cecilia³,Mfinanga Sayoki⁴⁵,Lesikari Sokoine⁴,Heyderman Robert S⁶⁷⁸^ORCID,Kalata Newton⁷⁸,Ellis Jayne⁷⁸⁹^ORCID,Kouanfack Charles¹⁰,Chanda Duncan¹¹,Temfack Elvis¹²¹³^ORCID,Lakhi Shabir¹⁴,Moodley Anand¹⁵,Chan Adrienne K¹⁶¹⁷,van Oosterhout Joep J¹⁸¹⁹,Mapoure Yacouba¹²,Mwaba Peter²⁰,Lalloo David G⁵,Wang Duolao⁵,Lortholary Olivier²¹²²,Jaffar Shabbar⁵,Hosseinipour Mina C³²³,Loyse Angela¹²,Harrison Thomas S¹²,Bicanic Tihana¹²^ORCID

Affiliation:

1. Centre for Global Health, Institute of Infection and Immunity, St George’s University of London, London, United Kingdom

2. Clinical Academic Group in Infection, St George’s University Hospital, LondonUnited Kingdom

3. UNC Project, Kamuzu Central Hospital, Lilongwe, Malawi

4. National Institute for Medical Research, Muhimbili Centre, Dar es Salaam, Tanzania

5. Liverpool School of Tropical Medicine, Liverpool, United Kingdom

6. University College London, London, United Kingdom

7. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi

8. College of Medicine, Queen Elizabeth Hospital, Blantyre, Malawi

9. The Hospital for Tropical Diseases, University College Hospital, LondonUnited Kingdom

10. Hȏpital Central Yaoundé/Site ANRS Cameroun, Yaoundé, Cameroon

11. Institute for Medical Research and Training, University Teaching Hospital, Lusaka, Zambia

12. Douala General Hospital, Douala, Cameroon

13. National Public Health Laboratory, Yaounde, Cameroon

14. University Teaching Hospital, Lusaka, Zambia

15. Department of Neurology, University of the Free State, Bloemfontein, South Africa

16. Dignitas International, Zomba Central Hospital, Zomba, Malawi

17. Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada

18. Partners in Hope, LilongweMalawi

19. David Geffen School of Medicine, University of California, Los Angeles, USA

20. Department of Internal Medicine and Directorate of Research and Post Graduate Studies, Lusaka Apex Medical University, Lusaka, Zambia

21. Institut Pasteur, Molecular Mycology Unit, Centre National de la Recherche Scientifique, Paris, France

22. Paris Descartes University, Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Institut Imagine, Assistance Publique – Hôpitaux de Paris, Paris, France

23. University of North Carolina, Chapel Hill, North Carolina, USA

Abstract

Abstract Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.

Funder

Medical Research Council

French Agency for Research on AIDS and Viral Hepatitis

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofab066/36199119/ofab066.pdf

Reference10 articles.

1. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis;Rajasingham;Lancet Infect Dis,2017

2. Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures;Bicanic;AIDS,2009