Amoxicillin and Ceftriaxone: A Synergistic Association Against Listeria monocytogenes

Author:

Sixt Thibault1ORCID,Moretto Florian1ORCID,Das Neves Sylvia1,Amoureux Lucie23ORCID,Neuwirth Catherine23,Piroth Lionel14,Blot Mathieu145,Chavanet Pascal14,Bador Julien2

Affiliation:

1. Department of Infectious Diseases, Dijon Bourgogne University Hospital , Dijon , France

2. Department of Bacteriology, Dijon Bourgogne University Hospital , Dijon , France

3. UMR/CNRS 6249 Chrono-environnement, University of Bourgogne-Franche-Comté , Besançon , France

4. INSERM, CIC1432, Clinical Epidemiology Unit, Clinical Investigation Center, Clinical Epidemiology/Clinical Trials Unit, Dijon Bourgogne University Hospital , Dijon , France

5. Lipness Team, INSERM Research Centre LNC-UMR1231 and LabEx LipSTIC, University of Burgundy   Dijon , France

Abstract

Abstract Among 15 strains of Listeria monocytogenes tested, a synergy between amoxicillin and ceftriaxone was observed in 14 (93%) according to minimal inhibitory concentration strips and 12 (80%) per the checkerboard methods, as well as for 2 of the 3 strains tested by the time-killing curve. This association may be an alternative treatment for listeriosis in the future.

Publisher

Oxford University Press (OUP)

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