Baricitinib Treatment of Coronavirus Disease 2019 Is Associated With a Reduction in Secondary Infections

Author:

Sweeney Daniel A1ORCID,Tuyishimire Bonifride2,Ahuja Neera3,Beigel John H4,Beresnev Tatiana4,Cantos Valeria D5,Castro Jose G6,Cohen Stuart H7,Cross Kaitlyn2,Dodd Lori E4,Erdmann Nathan8,Fung Monica9,Ghazaryan Varduhi4,George Sarah L10,Grimes Kevin A11,Hynes Noreen A12,Julian Kathleen G13,Kandiah Sheetal5,Kim Hannah Jang1415,Levine Corri B16,Lindholm David A1718,Lye David C19202122,Maves Ryan C23,Oh Myoung-don24,Paules Catharine13,Rapaka Rekha R25,Short Willam R26,Tomashek Kay M4,Wolfe Cameron R27,Kalil Andre C28

Affiliation:

1. Department of Medicine, University of California San Diego , La Jolla, CA , USA

2. The Emmes Company, LLC , Rockville, MD , USA

3. Department of Medicine, Stanford University , Palo Alto, CA , USA

4. National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD , USA

5. Department of Medicine, Emory University , Atlanta, GA , USA

6. Department of Medicine, University of Miami , Miami, FL , USA

7. Department of Internal Medicine, University of California Davis , Sacramento, CA , USA

8. Department of Medicine, University of Alabama at Birmingham (UAB) , Birmingham, AL , USA

9. Department of Medicine, University of California San Francisco , San Francisco, CA , USA

10. Department of Medicine, Saint Louis University and St. Louis VA Medical Center , Saint Louis, MO , USA

11. Department of Medicine, Houston Methodist , Houston, TX , USA

12. Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, MD , USA

13. Department of Medicine, Pennsylvania State Health Milton S. Hershey Medical Center , Hershey, PA , USA

14. Community Health Systems Department, University of California San Francisco , San Francisco, CA , USA

15. Department of Nursing, Kaiser Permanente National Patient Care Services , Oakland, CA , USA

16. Department of Internal Medicine Galveston, University of Texas Medical Branch , TX , USA

17. Department of Medicine, Uniformed Services University of the Health Sciences , Bethesda, MD , USA

18. Department of Medicine, Brooke Army Medical Center , Joint Base San Antonio-Ft Sam Houston, TX , USA

19. National Centre for Infectious Diseases , Singapore , Singapore

20. Department of Infectious Diseases, Tan Tock Seng Hospital , Singapore , Singapore

21. Lee Kong Chian School of Medicine , Singapore , Singapore

22. Yong Loo Lin School of Medicine , Singapore , Singapore

23. Departments of Internal Medicine and Anesthesiology , Wake Forest University, Winston-Salem, NC , USA

24. Department of Internal Medicine, Seoul National University Hospital College of Medicine , Seoul, Korea

25. Department of Medicine, Center for Vaccine Development and Global Health , University of Maryland School of Medicine, Baltimore, MD , USA

26. Department of Medicine, University of Pennsylvania , Philadelphia, PA , USA

27. Department of Medicine, Duke University , Durham, NC , USA

28. Department of Internal Medicine, University of Nebraska Medical Center , Omaha, NE , USA

Abstract

Abstract We performed a secondary analysis of the National Institutes of Health-sponsored Adaptive COVID-19 Treatment Trial (ACTT-2) randomized controlled trial and found that baricitinib was associated with a 50% reduction in secondary infections after controlling for baseline and postrandomization patient characteristics. This finding provides a novel mechanism of benefit for baricitinib and supports the safety profile of this immunomodulator for the treatment of coronavirus disease 2019.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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