Unlocking the Potential of Genomic Data to Inform Typhoid Fever Control Policy: Supportive Resources for Genomic Data Generation, Analysis, and Visualization

Author:

Carey Megan E123ORCID,Dyson Zoe A345ORCID,Argimón Silvia6,Cerdeira Louise7,Yeats Corin6,Aanensen David6,Mboowa Gerald8,Baker Stephen12,Tessema Sofonias K8,Smith Anthony M9ORCID,Okeke Iruka N10ORCID,Holt Kathryn E34ORCID

Affiliation:

1. Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge , Cambridge , United Kingdom

2. IAVI, Chelsea & Westminster Hospital , London , United Kingdom

3. Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine , London , United Kingdom

4. Department of Infectious Diseases, Central Clinical School, Monash University , Melbourne , Australia

5. Wellcome Sanger Institute, Wellcome Genome Campus , Hinxton , United Kingdom

6. Centre for Genomic Pathogen Surveillance, Big Data Institute, Nuffield Department of Medicine, University of Oxford , Oxford , United Kingdom

7. Department of Vector Biology, Liverpool School of Tropical Medicine , Liverpool , United Kingdom

8. Africa Centres for Disease Control and Prevention , Addis Ababa , Ethiopia

9. Division of the National Health Laboratory Service, Centre for Enteric Diseases, National Institute for Communicable Diseases , Johannesburg , South Africa

10. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan , Ibadan , Nigeria

Abstract

Abstract The global response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic demonstrated the value of timely and open sharing of genomic data with standardized metadata to facilitate monitoring of the emergence and spread of new variants. Here, we make the case for the value of Salmonella Typhi (S. Typhi) genomic data and demonstrate the utility of freely available platforms and services that support the generation, analysis, and visualization of S. Typhi genomic data on the African continent and more broadly by introducing the Africa Centres for Disease Control and Prevention's Pathogen Genomics Initiative, SEQAFRICA, Typhi Pathogenwatch, TyphiNET, and the Global Typhoid Genomics Consortium.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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