Long-term Protection Against Herpes Zoster by the Adjuvanted Recombinant Zoster Vaccine: Interim Efficacy, Immunogenicity, and Safety Results up to 10 Years After Initial Vaccination
Author:
Strezova Ana1, Diez-Domingo Javier2, Al Shawafi Kamal3, Tinoco Juan Carlos4, Shi Meng5, Pirrotta Paola6, Mwakingwe-Omari Agnes5, Adams Michael, Ahonen Anitta, Andrews Charles, Athan Eugene, BarbaGómez Jose-Fernando, Barbanti Piero, Barberan Elisabeth, Baty Alain, Bengtsson Niklas, Berger-Roscher Juergen, Blom Katarina Berndtsson, Beytout Jean, Boucher Loïc, Boutry Céline, Boye Alain, Brault François, Breger Laurie, Cuixart Carles Brotons, Caso Covadonga, Cerna Christine, Cheng Huey-Shinn, Cheong Hee Jin, Choo Eun Ju, Cunha Clóvis, Cunningham Anthony L, Curiac Dan, Daguzan Benoit, Dahmen Antje, Datta Susan, Desole Maria Giuseppina, Paolo Emmanuel Di, Dionne Marc, Dite Petr, Dutz Jan, Earl John, Eckermann Tamara, Ellison William, Eremenko Jurij, Esen Meral, Eto Takashi, Fabré Xavier Farrés, Farrington Cecil, Ferguson Murdo, Ferrand Pierre André, Finneran Matthew, Francyk David, Freedman Marshall, Freeman George, Freire Antônio Tarcísio, Gal Peter, Gauthier Jean-Sebastien, Gerlach Beatrice, Ghesquiere Wayne, Gorfinkel Iris, Grigat Christine, Grosskopf Josef, Hamann Monika, Hanrion Pascal, Hartley Paul, Hastie Andrew, Heaton Ken, Himpel-Boenninghoff Agnes, Horacek Thomas, Hui David Shu Cheong, Huong Yieng, Hwang Shinn-Jang, Icardi Giancarlo, Illies Gabriele, Irimajiri Junya, Jacob Wilson, Jambrecina Alen, Avelino-Silva Thiago Junqueira, Kalema George, Kim Hyo Youl, Klein Christiane, Kleinecke Uwe, Koenig Hans-Joachim, Kokko Satu, Kosina Pavel, Koski Susanna, Koskinen Pekka, Kropp Maximilian, Kuroki Rie, Laajalahti Outi, Lachance Pierre, Lee Jacob, Lee Jin-Soo, Levins Peter, Lipetz Robert, Liu Bo, Liu Chiu-Shong, Lundvall Martin, Magimaiseelan Luci, Manning Mary Beth, Markkula Jukka, Martin Frederick, Piera Pyrene Martínez, McNally Damien, McNeil Shelly, Migliorino Guglielmo, Moeckesch Beate, Morscher Stephan, Mueller Michael, Munir Abul Kashem, de Oliveira Cláudia Murta, Nakamura Kenjiro, Pérez Silvia Narejos, Naritomi Yuji, Nault Patrice, Neto José Luiz, López Concepción Núñez, Ogata Hiroaki, Olsson Åke, Paavola Pauliina, Park Dae Won, Patrick Janice, Pauksens Karlis, Vera Mercè Pérez, Peltonen Lauri, Plassmann Georg, Poder Airi, Poling Terry, Pretswell Carol, Purnell-Mullick Samir, Raad George, Redmond Michael, Remaud Philippe, Riffer Ernie, Robert Patrick, Badia Alex Rodríguez, de la Pinta Maria Luisa Rodríguez, Rombo Lars, Rosen Robert, Rozen Shari, Saillard Dominique, Salaun Bruno, Berglund Johan Sanmartin, Sauter Joachim, Schaefer Axel, Schenkenberger Isabelle, Schmidt Juergen, Schmitt Bernhard, Schubert Christian, Schuind Anne, Schwarz Tino, Seppa Ilkka, Sha Edmund Kwok Yiu, Shockey Gerald, Shoffner Sylvia, Sirnela-Rif Elina, Staniscia Tommaso, Sueki Hirohiko, Suzuki Shin, Taminau Denis, Tellier Guy, Riera Manuel Terns, Toma Azhar, Toursarkissian Nicole, Turner Mark, Ukkonen Benita, Morató Anna Vilella, Wachter Juergen, Webster Brian, Wilhelm Karl, Wilson Jonathan, Yeo Wilfred, Yu Chong-Jen, Zahaf Toufik, Zahharova Irina, Zerbini Cristiano,
Affiliation:
1. GSK , Rixensart , Belgium 2. FISABIO Fundación para el Fomento Investigación Sanitaria y Biomédica de la Comunitat Valenciana , Valencia , Spain 3. Modis, Belgium c/o GSK , Wavre , Belgium 4. Hospital General de Durango , Durango , Mexico 5. GSK , Rockville, Maryland , USA 6. GSK , Wavre , Belgium
Abstract
Abstract
Approximately 10 years after vaccination with the recombinant zoster vaccine (RZV), an interim analysis of this follow-up study of the ZOE-50/70 trials demonstrated that efficacy against herpes zoster remained high. Moreover, the safety profile remained clinically acceptable, suggesting that the clinical benefit of the RZV in ≥50-year-olds is sustained up to 10 years.
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
46 articles.
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