Nonquinolone Options for the Treatment of Mycoplasma genitalium in the Era of Increased Resistance

Author:

Doyle Michelle1,Vodstrcil Lenka A12,Plummer Erica L12,Aguirre Ivette1,Fairley Christopher K12,Bradshaw Catriona S12

Affiliation:

1. Melbourne Sexual Health Centre, Alfred Health, Carlton, Victoria, Australia

2. Central Clinical School, Monash University, Melbourne, Victoria, Australia

Abstract

Abstract In the era of increasing macrolide- and quinolone-resistant Mycoplasma genitalium (MG), we report the efficacy of 2 nonquinolone antimicrobials in patients with limited treatment options. Pristinamycin + doxycycline cured 75% (95% CI, 64%–85%), and minocycline cured 71% (95% CI, 54%–85%) of cases. These data provide useful estimates to inform clinical practice.

Funder

NHMRC

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference10 articles.

1. Quinolone resistance-associated mutations in Mycoplasma genitalium: not ready for prime time;Manhart;Sex Transm Dis,2020

2. New horizons in Mycoplasma genitalium treatment;Bradshaw;J Infect Dis,2017

3. Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis [published online ahead of print July 2, 2020];Machalek;Lancet Infect Dis,2020

4. Resistance-guided antimicrobial therapy using doxycycline-moxifloxacin and doxycycline-2.5 g azithromycin for the treatment of Mycoplasma genitalium infection: efficacy and tolerability [published online ahead of print October 20, 2019];Durukan;Clin Infect Dis,2019

5. Outcomes of resistance-guided sequential treatment of Mycoplasma genitalium infections: a prospective evaluation;Read;Clin Infect Dis,2019

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