Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions-Reference-Cited by-同舟云学术

Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions

Published:2020-12-28 Issue:1 Volume:8 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Marais Ben J¹^ORCID,Cheong Elaine²,Fernando Shelanah³,Daniel Santhosh⁴,Watts Matthew R¹⁵⁶,Berglund Lucinda J¹⁶,Barry Simone E⁷,Kotsiou George³,Headley Alex P⁸,Stapledon Richard A⁷

Affiliation:

1. The Marie Bashir Institute for Infectious Diseases and Biosecurity (MBI), University of Sydney, Sydney, Australia

2. Department of Infectious Diseases and Microbiology, Concord Repatriation General Hospital, Sydney, Australia

3. Department of Microbiology and Infectious Diseases, Royal North Shore Hospital, Sydney, Australia

4. Department of Infectious Diseases and Microbiology, Flinders Medical Centre and Flinders University, Adelaide, Australia

5. Centre for Infectious Diseases and Microbiology Infectious Diseases and Microbiology (CIDM), Westmead Hospital, Sydney, Australia

6. ICPMR Westmead Hospital, NSW Health Pathology, Sydney, Australia

7. Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia

8. Department of Clinical Immunology/Allergy, Concord Repatriation General Hospital, Sydney, Australia

Abstract

Abstract We documented dramatic responses to infliximab in 4 tuberculous meningitis cases with severe paradoxical reactions after effective antibacterial treatment, despite high-dose steroids. In every instance, infliximab was used as a last resort after all other options were exhausted, resulting in delayed initiation that may have adversely affected patient outcomes.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa604/35203568/ofaa604.pdf

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