Prior Pulmonary Tuberculosis Is a Risk Factor for Asymptomatic Cryptococcal Antigenemia in a Cohort of Adults With Advanced Human Immunodeficiency Virus Disease-Reference-Cited by-同舟云学术

Prior Pulmonary Tuberculosis Is a Risk Factor for Asymptomatic Cryptococcal Antigenemia in a Cohort of Adults With Advanced Human Immunodeficiency Virus Disease

Published:2022-04-17 Issue:7 Volume:9 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Wake Rachel M¹²³^ORCID,Ismail Nazir A⁴⁵⁶,Omar Shaheed V⁴⁵⁶,Ismail Farzana⁵⁶,Tiemessen Caroline T⁴⁷,Harrison Thomas S¹³⁸,Jarvis Joseph N⁹¹⁰¹¹,Govender Nelesh P¹²⁸¹²

Affiliation:

1. Institute for Infection and Immunity, St George’s University Hospital NHS Foundation Trust , London , United Kingdom

2. Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, a Division of the National Health Laboratory Service , Johannesburg , South Africa

3. Clinical Academic Group in Infection and Immunity, St George’s University Hospital NHS Foundation Trust , London , United Kingdom

4. Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

5. Department of Medical Microbiology, University of Pretoria , Pretoria , South Africa

6. Centre for Tuberculosis, National Institute for Communicable Diseases, a Division of the National Health Laboratory Service , Johannesburg , South Africa

7. Centre for HIV and STIs, National Institute for Communicable Diseases, a Division of the National Health Laboratory Service , Johannesburg , South Africa

8. MRC Centre for Medical Mycology, University of Exeter , Exeter , United Kingdom

9. Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine , London , United Kingdom

10. Botswana Harvard AIDS Institute Partnership , Gabarone , Botswana

11. Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania , USA

12. Division of Medical Microbiology, University of Cape Town , South Africa

Abstract

Abstract The greater mortality risk among people with advanced human immunodeficiency virus disease and cryptococcal antigenemia, despite treatment, indicates an increased susceptibility to other infections. We found that prior tuberculosis was an independent risk factor for cryptococcal antigenemia (adjusted odds ratio, 2.72; 95% confidence interval, 1.13–6.52; P = .03) among patients with CD4 counts <100 cells/µL.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofac202/43387218/ofac202.pdf

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1. Cryptococcal Antigenemia in Advanced Human Immunodeficiency Virus Disease: Pathophysiology, Epidemiology, and Clinical Implications;Clinical Infectious Diseases;2022-08-20

2. Association of Antibody Immunity With Cryptococcal Antigenemia and Mortality in a South African Cohort With Advanced Human Immunodeficiency Virus Disease;Clinical Infectious Diseases;2022-08-02