Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Patients Treated With Anti-CD20 Monoclonal Antibodies

Author:

Furie Nadav12ORCID,Mandelboim Michal23,Zuckerman Neta23,Belkin Ana45,Seluk Lior12,Shafran Inbal12,Mass Ronen1,Levy Liran12,Chatterji Sumit1,Baltaxe Erik12,Peled Michael12,Shulimzon Tiberiu1,Avigdor Abraham26,Amit Sharon7,Onn Amir12,Marom Edith M28,Rahav Galia25ORCID,Segel Michael J12

Affiliation:

1. Institute of Pulmonology, Sheba Medical Center , Tel Hashomer , Israel

2. Sackler Faculty of Medicine, Tel-Aviv University , Tel Aviv , Israel

3. Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center , Tel-Hashomer , Israel

4. Internal Medicine D, Sheba Medical Center , Tel Hashomer , Israel

5. Infectious Diseases Unit, Sheba Medical Center , Tel Hashomer , Israel

6. Division of Hematology and Bone-Marrow Transplantation, Sheba Medical Center , Ramat Gan , Israel

7. Microbiology Laboratory, Sheba Medical Center , Tel Hashomer , Israel

8. Department of Diagnostic Radiology, Sheba Medical Center , Tel Hashomer , Israel

Abstract

Abstract We report 8 cases of persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in patients previously treated with anti-CD20 monoclonal antibodies. Polymerase chain reaction of nasopharyngeal swabs for SARS-CoV-2 was negative in most cases; viral cell cultures confirmed that viable SARS-Co-2 virus was present. Four patients were treated with anti-SARS-CoV-2 hyperimmune globulins with rapid resolution of disease.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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