Mycoplasma genitalium and Antimicrobial Resistance Among a Cohort of West African Men Who Have Sex With Men Using Preexposure Prophylaxis (CohMSM-PrEP ANRS 12369-Expertise France Study)
Author:
De Baetselier Irith1ORCID, Vuylsteke Bea2, Cuylaerts Vicky1, Cuer Benjamin3, Yaya Issifou3, Mensah Ephrem4, Dah Elias5, Anoma Camille6, Koné Amadou7, Diandé Souba8, Dagnra Anoumou9, Fayé-Ketté Hortense10, Yeo Alain10, Smet Hilde1, Van den Bossche Dorien1, Keita Bintou Dembélé11, Spire Bruno12, Laurent Christian3, Crucitti Tania13, Laurent Christian, Yaya Issifou, Ouedraogo Sayouba, Granouillac Bruno, Cuer Benjamin, Serrano Laetitia, Peeters Martine, Spire Bruno, Sagaon-Teyssier Luis, Mora Marion, Maradan Gwenaëlle, Bourrelly Michel, Berenger Cyril, Boyer Sylvie, Castro Daniela Rojas, Riegel Lucas, Vuylsteke Bea, De Baetselier Irith, Reyniers Thijs, Crucitti Tania, Keita Bintou Dembélé, Diallo Fodié, Coulibaly Alou, Kader Maïga Alassane, Camara Drissa, Diarra Mahamadou, Ouologuem Aly, Sangaré Naboh, Keita Abdoul Aziz, Cissé Oumar, Traoré Fodé, Ouary Bréhima Abdrahamane, Kanta Ibrahima, Anoma Camille, Malan Jean-Baptiste, Kotchi Rachelle, Aka Niamkey Thomas, Lokrou Kpassou Julien, Coulibaly Noufo Hamed, Koffi Ekessi Jean Armel, N’guessan Dibi Frédéric, Yoro Stéphane-Alain Babo, Cissé Adama, Dah Ter Tiero Elias, Traoré Issa, Rajaonarivelo Camille, Ouedraogo Fayçal Rodrique, Ouedraogo Joseph, Coulibaly Christian, Ouedraogo Mamadou, Ilboudo Ousseni, Traoré Abdoulazziz, Comsiambo Honoré, Mensah Ephrem, Agboyibor Mawuényégan Kouamivi, Attisso Anani, Kokouba Anouwarsadat, Badjassim Aléda Mawuli, Agbomadji Kouakou Kokouvi Selom, Attiogbe Messan, Yaka Kossi Jeff, Ekon Agbégnigan Lorette, Bimba Julien, Dagnra Claver Anoumou, Tegueni Kokou Dominique,
Affiliation:
1. Clinical Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine , Antwerp , Belgium 2. Department of Public Health, Institute of Tropical Medicine , Antwerp , Belgium 3. TransVIHMI, Université Montpellier, Institut de Recherche pour le Développement, Inserm , Montpellier , France 4. Espoir Vie Togo , Lomé , Togo 5. Association African Solidarité , Ouagadougou , Burkina Faso 6. Espace Confiance , Abidjan , Côte d’Ivoire 7. University Center of Clinical Research, University of Sciences, Technics and Technologies of Bamako , Bamako , Mali 8. Laboratoire National de Référence de Tuberculose , Ouagadougou , Burkina Faso 9. Laboratoire des Mycobactéries , Lomé , Togo 10. Institut Pasteur Côte d’Ivoire , Abidjan , Côte d’Ivoire 11. ARCAD Santé PLUS , Bamako , Mali 12. Sciences économiques et sociales de la santé & traitement de l’information médicale, Aix-Marseille Université, Inserm, Institut de Recherche pour le Développement , Marseille , France 13. Institut Pasteur de Madagascar , Antanarivo , Madagascar
Abstract
Abstract
Background
Antimicrobial resistance to macrolides and fluoroquinolones in Mycoplasma genitalium (MG) among men who have sex with men (MSM) is worryingly high in high-resource countries. Data in Africa are lacking. We aimed to assess the burden of MG including the presence of resistance-associated mutations (RAMs) in MG among MSM using human immunodeficiency virus preexposure prophylaxis in Burkina Faso, Côte d’Ivoire, Mali, and Togo.
Methods
MSM were included in a prospective cohort study (2017–2021). Molecular detection of MG in urine, anorectal, and pharyngeal samples was performed at baseline and after 6 and 12 months. Detection of RAMs to macrolides and fluoroquinolones was performed by sequencing the 23S ribosomal RNA, parC, and gyrA genes. A sample was found to be possibly resistant to fluoroquinolones if alterations were found in ParC position 83/87.
Results
Of 598 participants, 173 (28.9%) were positive at least once for MG and global point-prevalence was 19.4%. Interestingly, 238 of 250 (95.2%) infections were asymptomatic and 72 of 138 MG infections with follow-up data (52.2%) cleared during the study. Only 1 macrolide RAM was found (0.6%). Prevalence of fluoroquinolones RAMs was 11.3% overall, ranging from 2.4% in Burkina Faso to 17.5% in Mali.
Conclusions
Although MG was highly prevalent in these MSM, macrolide resistance was almost nonexistent. Nevertheless, >10% of the samples were possibly resistant to fluoroquinolones. Heterogeneity in the prevalence of fluoroquinolone RAMs between countries may be explained by different antimicrobial consumption in humans and animals.
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
2 articles.
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