The Enterics for Global Health (EFGH) Shigella Surveillance Study in Malawi

Author:

Mategula Donnie123,Ndalama Maureen1,Lefu Clement1,Chinkhumba Jobiba3,Ndeketa Latif134,Munthali Vitumbiko1,Chitala Clifford1,Malemia Thandizo1,Million Gertrude1,Mbutuka Ishmail1,Mhone Ranken1,Makwenda Ethel1,James Mussa1,Bwanali Cornelius1,Kazembe Gift1,Manundo Abell1,Chauluka Evance1,Chitalo Salama1,Alumando Ethel1,Longwe Dalitso1,Matandika Maggie1,Jonasi Paul1,Thindwa Agra1,Phiri Deborah1,Wachepa Richard1,Kawonga Flywell1,Maiden Victor1,Charles Mary1,Kapindula Ida1,Witte Desiree14,Turner Ann M4,Bronowski Christina4,Baker Kate45,Bar-Zeev Naor6,Gordon Melita A14,Dube Queen78,Cunliffe Nigel A4,Jere Khuzwayo C147,Cornick Jennifer14

Affiliation:

1. Malawi Liverpool Wellcome Programme , Blantyre , Malawi

2. Clinical Sciences Department, Liverpool School of Tropical Medicine , Liverpool , United Kingdom

3. Department of Environmental and Community Health, School of Global Public Health, Kamuzu University of Health Sciences , Blantyre , Malawi

4. Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool , United Kingdom

5. Department of Genetics, University of Cambridge , Cambridge , United Kingdom

6. World Health Organization , Geneva , Switzerland

7. Department of Medical Laboratory Sciences, School of Life Sciences and Health Professions, Kamuzu University of Health Sciences , Blantyre , Malawi

8. Ministry of Health, Government of Malawi , Lilongwe , Malawi

Abstract

Abstract Background Malawi is among 7 countries participating in the Enterics for Global Health (EFGH) Shigella surveillance study, which aims to determine the incidence of medically attended diarrhea attributed to Shigella, a leading bacterial cause of diarrhea in children in low-resource settings. Methods We describe the EFGH study site in the densely populated informal settlement of Ndirande Township, Blantyre, Malawi. We explore the site’s geographical location, demographic characteristics, and the healthcare-seeking behavior of its population, particularly for childhood diarrhea. We also describe the management of childhood diarrhea at the health facility, and the associated challenges to attaining optimum adherence to local and national guidelines at the site. Conclusions Our overarching aim is to improve global health through understanding and mitigating the impact of diarrhea attributed to Shigella.

Funder

Bill & Melinda Gates Foundation

National Institute for Health and Care Research

NIHR Global Health Research

NIHR Health Protection Research

Publisher

Oxford University Press (OUP)

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