Clinical Features and Treatment Outcomes of Pulmonary Mycobacterium avium-intracellulare Complex With and Without Coinfections

Author:

Wang Grace1,Stapleton Jack T2,Baker Arthur W3,Rouphael Nadine4ORCID,Creech C Buddy5,El Sahly Hana M6,Stout Jason E3,Jackson Lisa7,Charbek Edward1,Leyva Francisco J8,Tomashek Kay M8,Tibbals Melinda8,Miller Aaron1,Frey Sharon1,Niemotka Samson1,Wiemken Timothy L1,Beydoun Nour4,Alaaeddine Ghina4,Turner Nicholas3,Walter Emmanuel B3,Chamberland Robin9,Abate Getahun1

Affiliation:

1. Department of Internal Medicine, Saint Louis University , St Louis, Missouri , USA

2. Department of Internal Medicine, University of Iowa , Iowa City, Iowa , USA

3. Duke University School of Medicine , Durham, North Carolina , USA

4. Department of Medicine, Emory University School of Medicine , Atlanta, Georgia , USA

5. Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University Medical Center , Nashville, Tennessee , USA

6. Baylor College of Medicine , Human Vaccine Institute, Houston, Texas , USA

7. Kaiser Permanente Washington Health Research Institute , Seattle, Washington , USA

8. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases , Bethesda, Maryland , USA

9. Department of Pathology, Division of Clinical Pathology, Saint Louis University School of Medicine , St Louis, Missouri , USA

Abstract

Coinfections are more common in patients with cystic fibrosis and bronchiectasis. Infiltrates on imaging studies are seen more commonly in patients with coinfections, but coinfections did not affect treatment outcomes of pulmonary Mycobacterium avium complex.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

vaccine and treatment evaluation units

Saint Louis University

Emory University School of Medicine

University of Iowa

Baylor College of Medicine

Duke University School of Medicine

Vanderbilt University Medical Center

Kaiser Permanente Washington Health Research Institute

Emmes Company

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference34 articles.

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2. Nontuberculous mycobacterial pulmonary infections;Johnson;J Thorac Dis,2014

3. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases;Griffith;Am J Respir Crit Care Med,2007

4. Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries;Adjemian;Am J Respir Crit Care Med,2012

5. Epidemiology of pulmonary nontuberculous mycobacterial disease, Japan;Namkoong;Emerg Infect Dis,2016

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