A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis-Reference-Cited by-同舟云学术

A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis

Published:2023-02-14 Issue:3 Volume:10 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Rammaert Blandine¹^ORCID,Bochud Pierre-Yves²,Brunel Anne-Sophie²,Wojtowicz Agnieszka²,Candon Sophie³,Gallego Hernanz Maria Pilar⁴,Lortholary Olivier¹⁵

Affiliation:

1. Université de Paris Cité, APHP, Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Centre d’Infectiologie Necker-Pasteur, Institut Imagine , Paris , France

2. Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, CHUV , Lausanne , Switzerland

3. INSERM U1234, CHU de Rouen Normandie, Université de Rouen Normandie , Rouen , France

4. CHU de Poitiers, Service d’Hématologie Adulte , Poitiers , France

5. Institut Pasteur, CNRS, Département de Mycologie, UMR 2000, Centre National de Référence Mycoses Invasives et Antifongiques , Paris , France

Abstract

AbstractWe investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

Funder

French Ministry of Health

Swiss National Science Foundation

Leenaards Foundation

Santos-Suarez Foundation, and by

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad078/49179803/ofad078.pdf

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