2595. Burden of Lower Respiratory Tract Infection in United States of America and its Trend from 1990-2019: A Benchmarking Analysis from the Global Burden of Disease Study

Abstract

Abstract Background Lower respiratory infections (LRIs) cause substantial mortality and morbidity in the United states of America (USA) accounting for 2.78% of all causes of deaths. However, there is a large statewide variation within the United States with regard to LRIs burden. Comparable and consistent state-level measures of total LRIs burden have not been produced previously. Methods We used Global Burden of Disease Methodology to estimate the burden of LRIs by Age-groups, year, sex, location across the USA. Results In 2019, there were 299,564(95% UI 281,732–317,390) prevalent cases of LRIs in the USA, with an age-standardized rate (ASR) of 85.2 (95% UI 78.8-91.9) per 100,000 population. The annual percentage change of total number incidence increased by 14% followed by deaths increased 13% from 1990-2019. Furthermore, Mississippi [20.49 (95% UI 17.4–23.9)] per 100,000 and Tennessee [19.1 (95% UI 16–22.5)]per 100,000 had the highest age-standardized mortality rate (ASMR) in 2019. In 2019, the incidence and DALY were highest in the 60-64 age group,75-79 age group respectively in both females and males. Age-Standardized Incidence, Mortality and DALYs Lower Respiratory Tract Infection in United States, 2019 Trend of Lower Respiratory Tract Infection in USA from 1990-2019 A) All age-counts, Incidence, Death, DALY B) Age-standardized rate Incidence, Death, DALY Sex-wise distribution of Lower Respiratory Tract Infection, Deaths, per 100,000 across the United States Conclusion LRIs continue to be a significant burden on the healthcare system in the United States, causing a significant economic impact and affecting vulnerable populations disproportionately. Preventive measures and prompt treatment can help reduce this burden and improve the overall health of the population. Disclosures All Authors: No reported disclosures