Disseminated <i>Mycoplasma Orale</i> Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations-Reference-Cited by-同舟云学术

Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations

Published:2022-09-01 Issue:9 Volume:9 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Totten Arthur H¹^ORCID,Uzel Gulbu²,Khil Pavel P¹²^ORCID,Youn Jung-Ho¹,Treat Jennifer²,Soutar Craig D¹^ORCID,Holland Steven M²^ORCID,Dekker John P¹²^ORCID,Zerbe Christa S²^ORCID

Affiliation:

1. Clinical Center, National Institutes of Health , Bethesda, Maryland , USA

2. National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA

Abstract

Abstract Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options.

Funder

Intramural Research Program

National Institutes of Health Clinical Center

National Institute of Allergy and Infectious Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofac472/45792052/ofac472.pdf

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