“Chronic Disseminated Aspergillosis,” a Novel Fungal Immune Reconstitution Inflammatory Syndrome

Author:

Pourbaix Annabelle1,Guery Romain1,Bruneau Julie2,Blanc Estelle3,Jouvion Gregory45,Weinandt Marthe6,Rouzaud Claire1,Lourenço Jérémy1,Boutboul David7,Mira Jean-Paul8,Rouquette Alexandre9,Molina Thierry Jo2,Lecuit Marc110,Lortholary Olivier111

Affiliation:

1. Paris University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, Paris, France

2. Pathology Department, Necker-Enfants Malades Hospital, AP-HP, Paris Descartes University, Paris, France

3. Nuclear Medicine Department, Marie Lannelongue Hospital, Le Plessis-Robinson, France

4. Pathophysiology of Pediatric Genetic Diseases, Sorbonne Université, INSERM, Assistance Publique Hôpitaux de Paris, Hôpital Armand-Trousseau, UF Génétique Moléculaire, Paris, France

5. Experimental Neuropathology Unit, Institut Pasteur, Paris, France

6. Visceral Surgery Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France

7. Clinical Immunopathology Department, St Louis Hospital, AP-HP, University of Paris, INSERM U967 HIPI, Paris, France

8. Medical Intensive Care Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France

9. Pathology Department, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France

10. Biology of Infection Unit, Institut Pasteur, INSERM U1117, Paris, France

11. Molecular Mycology Unit, Institut Pasteur, CNRS UMR2000, Paris, France

Abstract

Abstract We report a case of chronic hepatosplenic aspergillosis following immune reconstitution complicating colic aspergillosis in an AIDS patient with multicentric Castleman disease. Symptoms mimicked the clinical presentation of chronic disseminated candidiasis and responded to corticosteroid. This emerging entity enlarges the spectrum of fungal immune reconstitution inflammatory syndrome in the HIV setting.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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