Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals-Reference-Cited by-同舟云学术

Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals

Published:2021-12-18 Issue:2 Volume:9 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Ragozzino Silvio¹^ORCID,Goldenberger Daniel²,Wright Patrick R³^ORCID,Zimmerli Stefan⁴,Mühlethaler Konrad⁵,Neofytos Dionysios⁶^ORCID,Riat Arnaud⁷,Boggian Katia⁸,Nolte Oliver⁹,Conen Anna¹⁰,Fankhauser Hans¹¹,Schreiber Peter W¹²,Zbinden Reinhard¹³,Lamoth Frederic¹⁴,Khanna Nina¹^ORCID

Affiliation:

1. Division of Infectious Diseases and Hospital Epidemiology, University of Basel and University Hospital Basel, Basel, Switzerland

2. Clinical Bacteriology and Mycology, University of Basel and University Hospital Basel, Basel, Switzerland

3. Clinical Trial Unit, University Hospital Basel, Basel, Switzerland

4. Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland

5. Clinical Microbiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland

6. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Geneva, Geneva, Switzerland

7. Division of Laboratory Medicine, Laboratory of Bacteriology, University Hospital Geneva and University of Geneva, Geneva, Switzerland

8. Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland

9. Center for Laboratory Medicine, St Gallen, Switzerland

10. Clinic of Infectious Diseases and Hospital Hygiene, Cantonal Hospital Aarau, Aarau, Switzerland

11. Clinical Microbiology, Cantonal Hospital Aarau, Aarau, Switzerland

12. Division of Infectious Diseases and Hospital Epidemiology, University of Zurich and University Hospital Zurich, Zurich, Switzerland

13. Clinical Microbiology, University Hospital Zurich, Zurich, Switzerland

14. Infectious Diseases Service and Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland

Abstract

Abstract Among 400 Aspergillus species from respiratory samples in Switzerland, Aspergillus fumigatus was the most frequent species. Non-fumigatus Aspergillus spp were more prevalent among solid organ transplant recipients and after azole exposure. Azole resistance was detected in 4 A fumigatus isolates, 3 of them with the “environmental” mutation TR34/L98H in the cyp51A gene.

Funder

Schering-Plough

Gilead Sciences

Merck Sharp and Dohme

Novartis Foundation

Pfizer Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofab638/41819692/ofab638.pdf