Characterization of Early-Onset Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Patients Who Received Tixagevimab-Cilgavimab Prophylaxis

Author:

Ordaya Eloy E1ORCID,Beam Elena1ORCID,Yao Joseph D2ORCID,Razonable Raymund R1,Vergidis Paschalis1ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Mayo Clinic , Rochester, Minnesota , USA

2. Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, Minnesota , USA

Abstract

Abstract Tixagevimab-cilgavimab is authorized for preexposure prophylaxis against coronavirus disease 2019 (COVID-19) in immunocompromised hosts. Herein, we report the clinical characteristics of 8 patients who developed COVID-19 soon after receiving tixagevimab-cilgavimab. This study emphasizes the need to maintain additional measures to prevent COVID-19 during periods of high severe acute respiratory syndrome coronavirus 2 transmission.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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