Cholera Deaths During Outbreaks in Uvira, Eastern Democratic Republic of the Congo, 10–35 Months After Mass Vaccination

Author:

Bugeme Patrick Musole12ORCID,Xu Hanmeng1ORCID,Hutchins Chloe3ORCID,Dent Juan1ORCID,Saidi Jaime Mufitini4,Rumedeka Baron Bashige14,Itongwa Moïse5,Mashauri Joël Faraja Zigashane5,Masembe Lulela Faraja5,Bengehya Justin6,Kulondwa Jean-Claude6,Debes Amanda K7ORCID,Ciglenecki Iza8ORCID,Tshiwedi Esperance9,Kitoga Faida9,Bodisa-Matamu Tavia9,Nadège Taty10,Kavunga-Membo Hugo911ORCID,Lunguya Octavie11ORCID,Welo Placide Okitayemba10,Knee Jackie3ORCID,Mukadi-Bamuleka Daniel911ORCID,Azman Andrew S11213ORCID,Malembaka Espoir Bwenge12ORCID

Affiliation:

1. Department of Epidemiology, Johns Hopkins University , Baltimore, Maryland , USA

2. Centre for Tropical Diseases and Global Health (CTDGH), Université Catholique de Bukavu , Bukavu , Democratic Republic of the Congo

3. Department of Disease Control, London School of Hygiene & Tropical Medicine , London , UK

4. Zone de Santé d’Uvira, Ministère de la Santé Publique, Hygiène et Prévention , Uvira , Democratic Republic of the Congo

5. Oxfam GB , Uvira , Democratic Republic of the Congo

6. Division Provinciale de la Santé Publique du Sud-Kivu, Ministère de la Santé Publique, Hygiène et Prévention , Bukavu , Democratic Republic of the Congo

7. Department of International Health, Johns Hopkins University , Baltimore, Maryland , USA

8. Medical Department, Médecins Sans Frontières , Geneva , Switzerland

9. Rodolphe Merieux INRB-Goma Laboratory, Institut National de Recherche Biomédicale (INRB) , Goma , Democratic Republic of the Congo

10. Programme National d’Elimination de Choléra et de lutte contre les autres Maladies Diarrhéiques (PNECHOL-MD), Ministère de la Santé Publique, Hygiène et Prévention , Kinshasa , Democratic Republic of the Congo

11. Institut National de Recherche Biomédicale, INRB , Kinshasa , Democratic Republic of the Congo

12. Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals (HUG) , Geneva , Switzerland

13. Division of Tropical and Humanitarian Medicine, Geneva University Hospitals (HUG) , Geneva , Switzerland

Abstract

Abstract Our understanding of the burden and drivers of cholera mortality is hampered by limited surveillance and confirmation capacity. Leveraging enhanced clinical and laboratory surveillance in the cholera-endemic community of Uvira, eastern Democratic Republic of Congo, we describe cholera deaths across 3 epidemics between September 2021 and September 2023 following mass vaccination.

Funder

Wellcome Trust

Gavi

Publisher

Oxford University Press (OUP)

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