Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report

Author:

Wilson Lindsay1,Chang Ju-Wei1,Meier Stuart1,Ganief Tariq23,Ganief Naadir23,Oelofse Suzette1,Baillie Vicky45,Nunes Marta C45ORCID,Madhi Shabir A456,Blackburn Jonathan23,Dheda Keertan17

Affiliation:

1. Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute & South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town , Cape Town , South Africa

2. Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town , Cape Town , South Africa

3. Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town , South Africa

4. South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

5. Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

6. African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

7. Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene and Tropical Medicine , London , UK

Abstract

Abstract The pathogenesis of coronavirus disease 2019 (COVID-19) pneumonia remains poorly understood. The urine proteome of hospitalized patients with severe COVID-19 pneumonia, compared with severe non-COVID-19 pneumonia controls, was distinct and associated with lower abundance of several host proteins. Protein-specific machine learning analysis outlined biomarker combinations able to differentiate COVID-19 pneumonia from non-COVID-19 pneumonia controls.

Funder

Africa Rapid Grant Fund

Science Granting Councils Initiative in Sub-Saharan Africa

South Africa's National Research Foundation

Canada's International Development Research Centre

Swedish International Development Cooperation Agency

South Africa's Department of Science and Innovation

Fonds de Recherche du Québec

United Kingdom's Department of International Development

United Kingdom Research and Innovation

Newton Fund

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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