Effectiveness of BNT162b2 XBB Vaccine Against XBB and JN.1 Sublineages

Author:

Tartof Sara Y1ORCID,Slezak Jeff M1,Puzniak Laura2,Frankland Timothy B3,Ackerson Bradley K4ORCID,Jodar Luis2ORCID,McLaughlin John M2

Affiliation:

1. Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, California , USA

2. Global Vaccines and Antivirals, Pfizer Inc , Collegeville, Pennsylvania , USA

3. Center for Integrated Health Care Research (CIHR), Kaiser Permanente Hawaii , Honolulu, Hawaii , USA

4. Department of Pediatric Infectious Diseases, Southern California Permanente Medical Group , Harbor City, California , USA

Abstract

Abstract We provide updated results (11 October 2023 through 29 February 2024) from our previously conducted test-negative case-control study in Kaiser Permanente Southern California to evaluate sublineage-specific effectiveness of the BNT162b2 XBB1.5-adapted vaccine. Results suggest that XBB1.5-adapted vaccines may have reduced effectiveness against JN.1 versus XBB sublineages.

Funder

Pfizer

Publisher

Oxford University Press (OUP)

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