Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay-Reference-Cited by-同舟云学术

Detection of Free Toxin B in the Stool of Asymptomatic Clostridioides difficile Carriers by the Cell Cytotoxicity Neutralization Assay

Published:2021-04-25 Issue:6 Volume:8 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Schweitzer Lorne¹²³,Gervais Phillippe⁴⁵,Paquet-Bolduc Bianka⁴,Loo Vivian G¹²,Longtin Yves¹³

Affiliation:

1. McGill University Faculty of Medicine, Montreal, Québec, Canada

2. Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Québec, Canada

3. Division of Infectious Diseases, Department of Medicine, Jewish General Hospital, Montreal, Québec, Canada

4. Département de Microbiologie, Institut Universitaire de Cardiologie et Pneumologie de Québec, Québec City, Québec, Canada

5. Faculté de Médecine, Université Laval, Québec City, Québec, Canada

Abstract

Abstract Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose Clostridioides difficile infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic C. difficile carriers. Thirty-nine percent of specimens from asymptomatic carriers were positive. Thus, CCNA specificity may be lower than previously thought.

Funder

Fondation de l’Institut Universitaire de Cardiologie et Pneumologie de Québec

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofab209/37337524/ofab209.pdf

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