Mortality of Patients With Candidemia and COVID-19: A Systematic Review With Meta-analysis

Author:

Colaneri Marta12ORCID,Giusti Emanuele Maria3,Genovese Camilla14ORCID,Galli Lucia14,Lombardi Andrea45ORCID,Gori Andrea12

Affiliation:

1. Department of Clinical Sciences, Infectious Diseases and Immunopathology, Università di Milano, L. Sacco Hospital , Milan , Italy

2. Centre for Multidisciplinary Research in Health Science (MACH), University of Milano , Milano , Italy

3. EPIMED Research Center, Department of Medicine and Surgery, University of Insubria , Varese , Italy

4. Department of Pathophysiology and Transplantation, University of Milano , Milano , Italy

5. Infectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico , Milano , Italy

Abstract

Abstract Mortality of candidemia in coronavirus disease 2019 (COVID-19) patients has not been deeply studied despite evidence suggesting an increased occurrence. We performed a systematic review and meta-analysis to summarize the available evidence about these patients’ mortality and length of stay. Data about the in-hospital, all-cause and 30-day mortality, and length of stay were pooled. Subgroup analyses were performed to assess sources of heterogeneity. Twenty-six articles out of the 1915 records retrieved during the search were included in this review. The pooled in-hospital mortality was 62.62% (95% CI, 54.77% to 69.86%), while the mortality in intensive care unit (ICU) was 66.77% (95% CI, 57.70% to 74.75%). The pooled median in-hospital length of stay was 30.41 (95% CI, 12.28 to 48.55) days, while the pooled median length of stay in the ICU was 28.28 (95% CI, 20.84 to 35.73) days. The subgroup analyses did not identify the sources of heterogeneity in any of the analyses. Our results showed high mortality in patients with candidemia and COVID-19, suggesting the need to consider screening measures to prevent this life-threatening condition.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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