Prospective Clinical Assessments of Hospitalized Patients With Positive SARS-CoV-2 PCR Tests for Necessity of Isolation

Author:

Rhee Chanu123,Baker Meghan A1234,Kanjilal Sanjat12,Tucker Robert3,Vaidya Vineeta3,Badwaik Amy3,Blaeser Elizabeth Mermel3,Coughlin Cassie4,Elloyan Jennifer3,Hsieh Candace4,Holtzman Meghan3,Solem Ofelia3,Klompas Michael123

Affiliation:

1. Department of Population Medicine, Harvard Medical School/Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA

2. Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA

3. Infection Control Department, Brigham and Women’s Hospital, Boston, Massachusetts, USA

4. Infection Control Department, Dana Farber Cancer Institute, Boston, Massachusetts, USA

Abstract

Abstract We prospectively assessed 536 hospitalized patients with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction tests for infectiousness based on symptoms, cycle thresholds, and SARS-CoV-2 history, with repeat testing and serologies in select cases. One hundred forty-eight (28%) patients were deemed noninfectious, most with evidence of prior infection, and managed on standard precautions without evidence of transmission.

Funder

Centers for Disease Control and Prevention

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference14 articles.

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2. Predicting infectious severe acute respiratory syndrome coronavirus 2 from diagnostic samples;Bullard;Clin Infect Dis,2020

3. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020;Singanayagam;Euro Surveill,2020

4. Duration of culturable SARS-CoV-2 in hospitalized patients with COVID-19;Kim;N Engl J Med,2021

5. Antibody status and incidence of SARS-CoV-2 infection in health care workers;Lumley;N Engl J Med,2021

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