Considerations for the Selection and Use of Disinfectants Against SARS-CoV-2 in a Health Care Setting

Author:

Tyan Kevin12ORCID,Levin Adriane13,Avalos-Pacheco Alejandra145,Plana Deborah167,Rand Eleanor A18,Yang Helen14,Maliszewski Laura E14910,Chylek Lily A110,Atta Lyla111,Tye Mark A11213,Carmack Mary M1414,Oglesby N Synclaire19,Burgin Susan1215,Yu Sherry H116,LeBoeuf Nicole R135,Kemp Jacqueline M13

Affiliation:

1. Greater Boston Pandemic Fabrication Team (PanFab) c/o Harvard-MIT Center for Regulatory Science, Harvard Medical School, Boston, Massachusetts, USA

2. Harvard Medical School, Boston, Massachusetts, USA

3. Department of Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

4. Harvard-MIT Center for Regulatory Science, Harvard Medical School, Boston, Massachusetts, USA

5. Dana-Farber Cancer Institute, Boston, Massachusetts, USA

6. Harvard-MIT Division of Health Sciences & Technology, Cambridge, Massachusetts, USA

7. Harvard Ludwig Cancer Research Center and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA

8. Harvard University Department of Systems Biology, Cambridge, Massachusetts, USA

9. Harvard Program in Therapeutic Science, Cambridge, Massachusetts, USA

10. Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA

11. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

12. Harvard University Graduate School of Arts and Sciences, Cambridge, Massachusetts, USA

13. Massachusetts General Hospital Center for Systems Biology, Boston, Massachusetts, USA

14. Computational Health Informatics Program, Boston Children’s Hospital, Boston, Massachusetts, USA

15. Brigham and Women’s Hospital, Boston, Massachusetts, USA

16. Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA

Abstract

Abstract Proper disinfection using adequate disinfecting agents will be necessary for infection control strategies against coronavirus disease 2019 (COVID-19). However, limited guidance exists on effective surface disinfectants or best practices for their use against severe acute respiratory coronavirus 2. We outlined a process of fully characterizing over 350 products on the Environmental Protection Agency List N, including pH, method of delivery, indication for equipment sterilization, and purchase availability. We then developed a streamlined set of guidelines to help rapidly evaluate and select suitable disinfectants from List N, including practicality, efficacy, safety, and cost/availability. This resource guides the evaluation of ideal disinfectants amidst practical considerations posed by the COVID-19 pandemic.

Funder

Harvard MIT Center for Regulatory Sciences

National Institutes of Health

National Cancer Institute

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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