Incidence of Tuberculosis During the First Year of Antiretroviral Treatment in West African HIV-Infected Adults

Author:

Tchakounte Youngui Boris1,Coffie Patrick2,Messou Eugène23,Poda Armel4,Fortes Deguenonvo Louise5,Hawerlander Denise6,Minga Albert27,Balestre Eric8,Dabis François8,Marcy Olivier8ORCID

Affiliation:

1. University of Bordeaux, Bordeaux School of Public Health, ISPED, Bordeaux, France

2. Programme PACCI, site ANRS, Abidjan, Cote D’Ivoire

3. Centre de Prise en Charge de Recherche et de Formation, CePReF-Aconda-VS, Abidjan, Côte d’Ivoire

4. CHU Souro Sanou, Hôpital de Jour, Service des Maladies Infectieuses, Bobo Dioulasso, Burkina Faso

5. CHNU Fann, Service des Maladies Infectieuses et Tropicales Ibrahima Diop Mar, Dakar, Senegal

6. Centre Intégré de Recherches Biocliniques d’Abidjan, CIRBA, Abidjan, Cote D’Ivoire

7. Centre Médical de Suivi de Donneurs de Sang/CNTS/PRIMO-CI, Abidjan, Cote D’Ivoire

8. University of Bordeaux, Inserm, French National Research Institute for Sustainable Development (IRD), UMR 1219, Bordeaux, France

Abstract

Abstract We estimated tuberculosis incidence during the first year on antriretroviral therapy without isoniazid-preventive treatment in 6938 West African HIV-infected adults at 3.33 cases per 100 person-years (95% CI, 2.85–3.80). In multivariate Poisson models, sites in Cote d’Ivoire, male gender, low body mass index, low hemoglobin, low CD4 count, and young age were significantly associated with higher incidence.

Funder

National Cancer Institute

National Institute of Mental Health

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute of Allergy and Infectious Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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