Factors Associated With Hepatitis A Seropositivity at 23 Years After Childhood Vaccination-Reference-Cited by-同舟云学术

Factors Associated With Hepatitis A Seropositivity at 23 Years After Childhood Vaccination

Published:2024-06-28 Issue:7 Volume:11 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Scobie Heather M¹^ORCID,Negus Susan²,Stevenson Timothy¹,Bressler Sara¹,Bruden Dana¹,Simons Brenna C¹,Snowball Mary²,Hofmeister Megan G³,Bruce Michael¹,Townshend-Bulson Lisa²,Fischer Marc¹,McMahon Brian²

Affiliation:

1. Arctic Investigations Program, Centers for Disease Control and Prevention , Anchorage, Alaska , USA

2. Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium , Anchorage, Alaska , USA

3. Division of Viral Hepatitis, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

Abstract

Abstract We evaluated factors associated with the presence of hepatitis A virus antibodies 23 years after initiating vaccination at ages 6–15 months. Among 67 participants, 86% (42/49) of those vaccinated at ages 12–15 months and 61% (11/18) of those vaccinated at 6 months remained seropositive at 23 years. Lack of maternal antibodies at enrollment and higher initial vaccine response were independently associated with higher antibody concentrations at 23 years. Further research is needed to assess the duration of hepatitis A vaccine protection and possible need for a booster dose.

Funder

Centers for Disease Control and Prevention

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae417/58586330/ofae417.pdf

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