Genome-wide CRISPR screens identify PTPN21 and WDR26 as modulators of the mitochondrial stress-induced ISR-Reference-Cited by-同舟云学术

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Genome-wide CRISPR screens identify PTPN21 and WDR26 as modulators of the mitochondrial stress-induced ISR

Published:2024-05-28 Issue:4 Volume:3 Page:
ISSN:2755-0230
Container-title:Life Metabolism
language:en
Short-container-title:

Author:

Li Wen¹²,Dong Mingyue¹²,Gao Kaiyu¹,Guan Jialiang¹³,Liu Ying¹²⁴^ORCID

Affiliation:

1. State Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Institute of Molecular Medicine, College of Future Technology, Peking University , Beijing 100871 , China

2. Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University , Beijing 100871 , China

3. PKU-Tsinghua-NIBS Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University , Beijing 100871 , China

4. Beijing Advanced Innovation Center for Genomics , Beijing 100871 , China

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/lifemeta/advance-article-pdf/doi/10.1093/lifemeta/loae020/57946627/loae020.pdf

Reference36 articles.

1. The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

2. The Mitochondrial Basis of Aging

3. A Futile Battle? Protein Quality Control and the Stress of Aging

4. An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

5. Integrated stress response of vertebrates is regulated by four eIF2α kinases

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