Successful Treatment of Mycobacterium chelonae Keratitis Within a Corneal Transplant Using Intrastromal Amikacin Injections—A Case Report Demonstrating the Fundamental Principles and Challenges of Infective Keratitis Management and Novel Therapeutic Approaches

Author:

Merridew Nancy Louisa1,Phagura Ravinder Singh2,Anderson Edward3,Cooley Louise Anne1,Pollock Graeme Alfred4,McEwan Belinda1,McCartney Paul James5,Trad Mohamad-Ali1

Affiliation:

1. Department of Microbiology and Infectious Diseases, Royal Hobart Hospital, Hobart, Australia

2. Royal Perth Hospital, Perth, Australia

3. Department of Pharmacy, Royal Hobart Hospital, Hobart, Australia

4. Centre for Eye Research Australia, The University of Melbourne, Melbourne, Australia

5. Hobart Eye Surgeons, Hobart, Australia

Abstract

AbstractMycobacterium chelonae keratitis is rare and difficult to treat. This is the first known case worldwide of effective treatment using intrastromal amikacin injections in a corneal transplant recipient who had metastatic breast cancer. The challenges and principles of management, applicable to other causes of infective keratitis, are reviewed.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference14 articles.

1. Manual of Clinical Microbiology

2. Nontuberculous mycobacterial ocular and adnexal infections;Moorthy;Surv Ophthalmol,2012

3. Review: non-tuberculous mycobacterial keratitis;Chu;Clin Microbiol Infect,2013

4. Ocular infections due to non-tuberculous mycobacteria;Lalitha;Indian J Med Microbiol,2004

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