Detection and Characterization of Influenza B Virus with Reduced Neuraminidase Susceptibility in a Stem Cell Transplant Recipient

Author:

Kodiyanplakkal Rosy Priya L1,Laplante Jennifer M2,Westblade Lars F13,van Besien Koen1,Salvatore Mirella1,St. George Kirsten2

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA

2. Laboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA

3. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA

Abstract

Abstract Antiviral-resistant influenza viruses in the clinical environment, especially type B, are rarely reported. A stem cell transplant recipient remained influenza B positive for two months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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