Genetic Evidence That Naive T Cells Can Contribute Significantly to the Human Immunodeficiency Virus Intact Reservoir: Time to Re-evaluate Their Role
Author:
Affiliation:
1. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
2. Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Italy
Funder
National Institutes of Health
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Microbiology (medical)
Link
http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz378/28847039/ciz378.pdf
Reference5 articles.
1. Naive CD4+ T cells harbor a large inducible reservoir of latent, replication-competent HIV-1;Zerbato;Clin Infect Dis,2019
2. Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion;Pinzone;Nat Commun,2019
3. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation;Chomont;Nat Med,2009
4. Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants;Hiener;Cell Rep,2017
5. Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells;Dai;J Virol,2009
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