Patterns of community antibiotic use with reference to the AWaRe classification of the World Health Organization

Abstract

Abstract Background Monitoring consumption through quality indicators and providing feedback is an important activity within programmes for improving antibiotic prescription. This study aims to describe the use of antibiotics for systemic use in community setting in Italy and to compare prescription patterns among regions based on quality prescription indicators to identify any inter-regional variability. Methods The 2021 consumption (calculated as DDDs per 1000 inhabitants per day) of antibiotics for systemic use (reimbursed or purchased privately) in community setting were considered. The WHO AWaRe system was used to classify antibiotics into Access, Watch and Reserve groups, using the 60% of prescribed antibiotics belonging to the Access group out of the total DDDs as AWaRe target. The correlation between regional consumption and percentages of DDDs in the Access group was assessed through linear regression. A further indicator ‘ratio of broad to narrow-spectrum antibacterials’ was also calculated to compare the spectrum of prescribed antibiotics. Findings Overall community antibiotic consumption in Italy in 2021 was 15.6 DDDs per 1000 inhabitants per day, with an increasing trend from north (13.0 DDDs) to south (19.5 DDDs) and the percentages of non-reimbursed consumption decreasing from north (33.1%) to south (21.5%). Only three regions out of 21 reached the AWaRe target (regional range 47.4%–62.9%), with a negative correlation between regional consumption and percentages of antibiotics belonging to the Access group (correlation coefficient −0.8; R2 = 0.64; P value < 0.001). The ‘ratio of broad to narrow-spectrum antibacterials’ was 8.5 at national level, with the highest value in the centre (11.0) compared to the south (9.1) and north (7.0). Conclusion The percentage of consumption of Access group antibiotics correlates very well with regional consumption in Italy, indicating that regions with higher antibiotics consumption also have worse prescribing patterns with a greater impact on bacterial resistance. Additional data are needed to better describe prescription patterns from an antimicrobial stewardship perspective.