Phenotypic and genomic analysis of bacteria from war wounds in Dnipro, Ukraine

Author:

Stepanskyi Dmytro1ORCID,Ishchenko Oksana1,Luo Ting2,Lebreton Francois2,Bennett Jason W2,Kovalenko Iryna3,McGann Patrick2

Affiliation:

1. Department of Microbiology, Virology, Immunology, Epidemiology and Biomedical Physics and Informatics, Dnipro State Medical University , Dnipro , Ukraine

2. Multidrug-Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research , Silver Spring, MD , USA

3. Department of Microbiology, National Pirogov Memorial Medical University , Vinnytsia , Ukraine

Abstract

Abstract Objectives To better understand the source and potential transmission routes of antibiotic-resistant bacteria infecting injured service members in Ukraine. Methods Phenotypic and genomic characterizations were performed on 11 Gram-negative pathogens cultured from war wounds at an intermediate evacuation hospital in Dnipro. Results The analysis revealed both susceptible and extensively drug-resistant strains present in cultures, including high-risk global clones carrying carbapenemases. Conclusions Globally distributed carbapenemase-producing lineages are being acquired early in the medical evacuation process.

Funder

U.S. Department of the Army, Operation and Maintenance, Army

Publisher

Oxford University Press (OUP)

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