SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens

Author:

Chung Yu Jin1ORCID,Park Kyung Chan2ORCID,Tokar Sergiy3ORCID,Eykyn Thomas R13ORCID,Fuller William4ORCID,Pavlovic Davor5ORCID,Swietach Pawel2ORCID,Shattock Michael J1ORCID

Affiliation:

1. British Heart Foundation Centre of Research Excellence, King’s College London, UK

2. Burdon Sanderson Cardiac Science Centre, Department of Anatomy, Physiology and Genetics, University of Oxford, Oxford, UK

3. School of Biomedical Engineering and Imaging Sciences, King’s College London, UK

4. Institute of Cardiovascular & Medical Sciences, University of Glasgow, UK

5. Institute for Cardiovascular Sciences, University of Birmingham, UK

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference12 articles.

1. Off-target effects of SGLT2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart;Chung;Cardiovasc Res,2021

2. SGLT2 inhibitor Empagliflozin inhibits the cardiac Na+/H+ exchanger 1: persistent inhibition under various experimental conditions;Zuurbier;Cardiovasc Res,2021

3. Does the cardioprotective effect of Empagliflozin involve inhibition of the sodium-proton exchanger?;Murphy;Cardiovasc Res,2021

4. Pseudoreplication in physiology: more means less;Eisner;J Gen Physiol,2021

5. S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart;Ch'en;Br J Pharmacol,2008

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