Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty

Author:

Cousminer Diana L.1,Stergiakouli Evangelia2,Berry Diane J.3,Ang Wei4,Groen-Blokhuis Maria M.56,Körner Antje7,Siitonen Niina8,Ntalla Ioanna910,Marinelli Marcella111213,Perry John R.B.14,Kettunen Johannes115,Jansen Rick61617,Surakka Ida115,Timpson Nicholas J.2,Ring Susan18,Mcmahon George18,Power Chris3,Wang Carol4,Kähönen Mika19,Viikari Jorma20,Lehtimäki Terho21,Middeldorp Christel M.51617,Hulshoff Pol Hilleke E.22,Neef Madlen7,Weise Sebastian7,Pahkala Katja823,Niinikoski Harri824,Zeggini Eleftheria25,Panoutsopoulou Kalliope25,Bustamante Mariona111326,Penninx Brenda W.J.H.61617,Murabito Joanne27,Torrent Maties1328,Dedoussis George V.9,Kiess Wieland7,Boomsma Dorret I.5616,Pennell Craig E.4,Raitakari Olli T.829,Hyppönen Elina33031,Davey Smith George2,Ripatti Samuli13225,McCarthy Mark I.333435,Widén Elisabeth1, ,

Affiliation:

1. Institute for Molecular Medicine Finland (FIMM)

2. MRC Integrative Epidemiology Unit

3. Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK

4. School of Women's and Infants’ Health, The University of Western Australia, Perth, WA, Australia

5. Department of Biological Psychology

6. EMGO+ Institute for Health and Care Research

7. Center of Pediatric Research, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany

8. Research Centre of Applied and Preventive Cardiovascular Medicine

9. Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece

10. Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK

11. Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catelonia, Spain

12. Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain

13. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Catalonia, Spain

14. MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK

15. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

16. Neuroscience Campus Amsterdam, VU University, Amsterdam, the Netherlands

17. Department of Psychiatry, VU University Medical Center/GGZ inGeest, Amsterdam, The Netherlands

18. Avon Longitudinal Study of Parents and Children (ALSPAC), School of Social and Community Medicine, University of Bristol, Bristol, UK

19. Department of Clinical Physiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere 33521, Finland

20. Department of Medicine, University of Turku and Turku University Hospital, Turku 20521, Finland

21. Department of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland

22. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands

23. Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health

24. Department of Pediatrics, University of Turku, Turku, Finland

25. Wellcome Trust Sanger Institute, Hinxton, UK

26. Genes and genomes, Center for Genomic Regulation (CRG), Barcelona, Catalonia, Spain and

27. Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA

28. ib-salut, Area de Salut de Menorca, Balearic Islands, Spain

29. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

30. School of Population Health and Sansom Institute for Health Research, University of South Australia, North Terrace, Adelaide, Australia

31. South Australian Health and Medical Research Institute, North Terrace, Adelaide, Australia

32. Hjelt Institute, University of Helsinki, Helsinki, Finland

33. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, UK

34. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

35. Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK,

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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