Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice-Reference-Cited by-同舟云学术

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

Published:2018-05-22 Issue:11 Volume:46 Page:5366-5380
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Hagedorn Peter H¹,Pontoppidan Malene¹²,Bisgaard Tina S¹,Berrera Marco³,Dieckmann Andreas³,Ebeling Martin³,Møller Marianne R¹,Hudlebusch Heidi¹,Jensen Marianne L¹,Hansen Henrik F¹,Koch Troels¹,Lindow Morten¹

Affiliation:

1. Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark

2. Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark

3. Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland

Funder

Danish Strategic Research Council

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/46/11/5366/25067601/gky397.pdf

Reference42 articles.

1. Enzyme from calf thymus degrading the RNA moiety of DNA-RNA Hybrids: Effect on DNA-Dependent RNA polymerase;Stein;Science,1969

2. RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery;Lima;Nucleic Acids Res.,2016

3. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide;Zamecnik;PNAS,1978

4. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial;Raal;Lancet.,2010

5. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform;Bennett;Annu. Rev. Pharmacol. Toxicol.,2010

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