“Hemispheric pilocytic astrocytoma” revisited: A comprehensive clinicopathological and molecular series emphasizing their overlap with other glioneuronal tumors

Author:

Mariet Cassandra12,Grill Jacques23ORCID,Ajlil Yassine34,Castel David34,Dangouloff-Ros Volodia56,Boddaert Nathalie56,Meurgey Alexandra78,Pissaloux Daniel78,Appay Romain910,Saffroy Raphaël11,Puget Stéphanie1213,Blauwblomme Thomas12ORCID,Beccaria Kévin12ORCID,Hasty Lauren1,Rigau Valérie14,Roujeau Thomas15,Aline-Fardin Aude16,Chrétien Fabrice117,Métais Alice117,Varlet Pascale117,Tauziède-Espariat Arnault117

Affiliation:

1. Department of Neuropathology, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne , Paris, France

2. Department of Pediatric Oncology, Gustave Roussy, Université Paris-Saclay , Villejuif, France

3. U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay , Villejuif, France

4. Department of Child and Adolescent Oncology, Gustave Roussy , Villejuif, France

5. Pediatric Radiology Department, Hôpital Necker Enfants Malades, AP-HP , Paris, France

6. Department UMR 1163, Institut Imagine and INSERM U1299, Université Paris Cité , Paris, France

7. Department of Biopathology, Léon Bérard Cancer Center , Lyon, France

8. Department CNRS 5286, INSERM 1052, Cancer Research Center of Lyon (CRCL) , Lyon, France

9. Department of Pathology and Neuropathology, APHM, CHU Timone , Marseille, France

10. Institute of Neurophysiopathol, CNRS, INP, Aix-Marseille University , Marseille, France

11. Department of Biochemistry and Oncogenetic, Paul Brousse Hospital , Villejuif, France

12. Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cite , Paris, France

13. Department of Neurosurgery, CHU Martinique , Fort-de-France, France

14. Department of Pathology, Gui de Chauliac Hospital , Montpellier, France

15. Department of Neurosurgery, Gui de Chauliac Hospital , Montpellier, France

16. Department of Pathology, CHU Martinique , Fort-de-France, France

17. Institute of Psychiatry and Neuroscience of Paris (IPNP), Ima-Brain Team, INSERM U1266, Université Paris Cité , Paris, France

Abstract

Abstract Pilocytic astrocytomas (PA) typically exhibit distinct clinical, radiological, histopathological, and genetic features. DNA-methylation profiling distinguishes PA according to their location (infratentorial, midline, hemispheric, or spinal). In the hemispheric location, distinguishing PA from glioneuronal tumors remains a common diagnostic challenge for neuropathologists. Furthermore, the current version of the DKFZ classifier seems to have difficulty separating them from gangliogliomas. In this study, after central radiological review, we identified a histopathologically defined set of PA (histPA, n = 11) and a cohort of DNA-methylation defined PA (mcPA, n = 11). Nine out of the 11 histPA matched the methylation class of hemispheric PA, whereas 2 cases were classified at the end of the study as dysembryoplastic neuroepithelial tumors. Similarly, the mcPA cohort contained tumors mainly classified as PA (7/11), but 4 cases were classified as glioneuronal. The analysis of the 16 tumors with an integrated diagnosis of PA revealed that they affect mainly children with a wide spectrum of radiological, histopathological (i.e. a predominantly diffuse growth pattern), and genetic characteristics (large range of mitogen-activated protein kinase alterations). Based on these results, we consider hemispheric PA to be different from their counterparts in other locations and to overlap with other glioneuronal tumors, reinforcing the necessity of interpreting all data to obtain an accurate diagnosis.

Funder

l’Etoile de Martin

Carrefour Foundation “Les Boucles du Coeur”

Publisher

Oxford University Press (OUP)

Reference21 articles.

1. Adult patients with supratentorial pilocytic astrocytoma: long-term follow-up of prospective multicenter clinical trial NCCTG-867251 (Alliance);Brown;Neurooncol Pract,2015

2. A population-based study of the incidence and survival rates in patients with pilocytic astrocytoma;Burkhard;J Neurosurg,2003

3. Pediatric spinal pilocytic astrocytomas form a distinct epigenetic subclass from pilocytic astrocytomas of other locations and diffuse leptomeningeal glioneuronal tumours;Métais;Acta Neuropathol,2023

4. Pilocytic astrocytoma: Pathology, molecular mechanisms and markers;Collins;Acta Neuropathol,2015

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Glioneuronal and neuronal tumors: A perspective;Pathology International;2024-09-06

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3