WormBase: a modern Model Organism Information Resource

Author:

Harris Todd W1ORCID,Arnaboldi Valerio2,Cain Scott1,Chan Juancarlos2,Chen Wen J2,Cho Jaehyoung2,Davis Paul3,Gao Sibyl1,Grove Christian A2,Kishore Ranjana2,Lee Raymond Y N2,Muller Hans-Michael2,Nakamura Cecilia2,Nuin Paulo1,Paulini Michael3,Raciti Daniela2,Rodgers Faye H4,Russell Matthew3ORCID,Schindelman Gary2,Auken Kimberly V2,Wang Qinghua2,Williams Gary3,Wright Adam J1,Yook Karen2,Howe Kevin L3,Schedl Tim5,Stein Lincoln1,Sternberg Paul W2

Affiliation:

1. Informatics and Bio-computing Platform, Ontario Institute for Cancer Research, Toronto, ON M5G0A3, Canada

2. Division of Biology and Biological Engineering 156–29, California Institute of Technology, Pasadena, CA 91125, USA

3. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

4. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK

5. Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA

Abstract

Abstract WormBase (https://wormbase.org/) is a mature Model Organism Information Resource supporting researchers using the nematode Caenorhabditis elegans as a model system for studies across a broad range of basic biological processes. Toward this mission, WormBase efforts are arranged in three primary facets: curation, user interface and architecture. In this update, we describe progress in each of these three areas. In particular, we discuss the status of literature curation and recently added data, detail new features of the web interface and options for users wishing to conduct data mining workflows, and discuss our efforts to build a robust and scalable architecture by leveraging commercial cloud offerings. We conclude with a description of WormBase's role as a founding member of the nascent Alliance of Genome Resources.

Funder

National Human Genome Research Institute

Medical Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference20 articles.

1. WormBase: network access to the genome and biology of Caenorhabditis elegans;Stein;Nucleic Acids Res.,2001

2. WormBase: a cross-species database for comparative genomics;Harris;Nucleic Acids Res.,2003

3. WormBase 2014: New views of curated biology;Harris;Nucleic Acids Res.,2014

4. Automatic categorization of diverse experimental information in the bioscience literature;Fang;BMC Bioinformatics,2012

5. Update on Protein-Protein Interaction Data in WormBase;Cho;microPublication Biology,2018

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