The field of avian infectious disease ecology is at a key precipice, poised for exciting new ‘flight paths’ in the coming decades. Given the enormous human interest in birds, the unique biology of birds, and the scientific tractability of many avian species, birds represent ideal study systems for generating important insights for the field of infectious disease ecology more broadly. A flight path forward for avian infectious disease ecology must leverage these unique characteristics of birds to bridge and integrate across disciplines and scales, from the levels of biological organization (individual to community) to the spatial and temporal units of analysis. The broader field of One Health provides a key framework for transdisciplinary work that recognizes and studies avian infectious disease as intimately interconnected to that of human and ecosystem health. The flight path forward for avian infectious disease ecology should also continue to leverage the highly engaged community scientists in several parts of the world who collect data relevant to avian disease across unprecedented spatial scales. Finally, the flight path forward for avian infectious disease should leverage technological innovations to improve our ability to track avian movements, from those occurring within forest patches or cities up to those that cross hemispheres. With effective community engagement, transdisciplinary collaboration, and technological innovation, the flight path forward for avian infectious disease ecology can, just like birds themselves, know no boundaries.