This chapter addresses the dynamic balance between human health and the environment, with a focus on the global health and human rights threat of climate change. International legal efforts to mitigate environmental damage and climate change—from the 1992 United Nations Framework Convention on Climate Change and its 1997 Kyoto Protocol to the 2015 Paris Agreement—have been limited in addressing the threats posed to global health. Human rights will be necessary to examine efforts to mitigate and respond to these cataclysmic threats, including rising temperatures and extreme weather events, air pollution, infectious diseases, food, water and sanitation, and mental health. Facing this unprecedented threat, advocates can draw from past advances, including the use of litigation to protect human rights affected by the environment, the realization of the right to enjoy the benefits of scientific progress, and the implementation of human rights as a foundation of planetary health.