Regional variations in South America’s weather and climate reflect the atmospheric circulation over the continent and adjacent oceans, involving mean climatic conditions and regular cycles, as well as their variability on timescales ranging from less than a few months to longer than a year. Rather than surveying mean climatic conditions and variability over different parts of South America, as provided by Schwerdtfeger and Landsberg (1976) and Hobbs et al. (1998), this chapter presents a physical understanding of the atmospheric phenomena and precipitation patterns that explain the continent’s weather and climate. These atmospheric phenomena are strongly affected by the topographic features and vegetation patterns over the continent, as well as by the slowly varying boundary conditions provided by the adjacent oceans. The diverse patterns of weather, climate, and climatic variability over South America, including tropical, subtropical, and midlatitude features, arise from the long meridional span of the continent, from north of the equator south to 55°S. The Andes cordillera, running continuously along the west coast of the continent, reaches elevations in excess of 4 km from the equator to about 40°S and, therefore, represents a formidable obstacle for tropospheric flow. As shown later, the Andes not only acts as a “climatic wall” with dry conditions to the west and moist conditions to the east in the subtropics (the pattern is reversed in midlatitudes), but it also fosters tropical-extratropical interactions, especially along its eastern side. The Brazilian plateau also tends to block the low-level circulation over subtropical South America. Another important feature is the large area of continental landmass at low latitudes (10°N–20°S), conducive to the development of intense convective activity that supports the world’s largest rain forest in the Amazon basin. The El Niño–Southern Oscillation phenomenon, rooted in the ocean-atmosphere system of the tropical Pacific, has a direct strong influence over most of tropical and subtropical South America. Similarly, sea surface temperature anomalies over the Atlantic Ocean have a profound impact on the climate and weather along the eastern coast of the continent. In this section we describe the long-term annual and monthly mean fields of several meteorological variables.