Climate change threatens humanity and the planet on which we live. Social inequities, including in the health outcomes that different population groups enjoy, also pose a threat to humanity and our freedom to live healthy and flourishing lives. This book makes three key contributions to the current understanding of climate change and health inequity. First, it describes how climate change interacts with the social determinants of health and exacerbates existing health inequities. Second, the book introduces the concept of a “consumptagenic system.” This is an integrated network of market-based policies, processes, governance, and modes of understanding that fuel unhealthy and environmentally destructive production and consumption. Finally, the book outlines some of the progressive steps that are necessary to move from denial and inertia toward effective mobilization against the status quo and hope for the future. The book argues that this requires a systems approach and calls for action that uses fit-for-purpose knowledge and analytical tools from across the sciences, social sciences, and even humanities. The book finishes with the offer of a policy vision and describes some pathways forward across economic, social, and health policy domains that will reduce inequality, mitigate further environmental degradation, and improve health.