Responsible Conduct of Research provides an overview of ethical, legal, and social issues in scientific research for science students, trainees, and professional scientists. Written by two leading scholars in the field of research ethics, one with a background in natural science and the other with a background in philosophy and law, the book incorporates insights from these diverse disciplines throughout the text. The book provides in-depth analyses of a wide array of topics, including ethical theory and decision-making, misconduct, questionable research practices, research record-keeping, data sharing, data auditing, reproducibility, authorship, publication, peer review, intellectual property, conflict of interest, mentoring, safe research environment, animal experimentation, research with human subjects, and social responsibility. The book also includes interesting case studies and provocative questions at the end of each chapter that can serve as a basis for further analysis and discussion. The concluding chapter of the book describes some steps that researchers, institutional officials, government agencies, and scientific organizations can take to promote ethical conduct in scientific research. The 4th edition of Responsible Conduct of Research includes updated references and discussions of new and evolving topics, such as digital image manipulation, text recycling (sometimes called self-plagiarism), retractions, publication on pre-print servers, sexual and other forms of harassment, research with human biological samples, revisions to the Common Rule for research with human subjects, dual use research, the COVID-19 pandemic, providing science advice, and interactions with the media.