The Italian experience represents a historical example that education and sociopolitical vision can effectively contribute to the conquest of malaria. Until the end of 19th century, the infection spread mostly in the Central and Southern parts of Italy, with about 7 percent of the population affected and 20,000 annual deaths. Malaria showed different facies, owing to a complex vectorial system with remarkable ecological and behavioral differences. With the involvement of a critical mass of scientists and physicians, the etiology of malaria and the biological and socioeconomics determinants of the transmission dynamics were identified. This provided the opportunity to break the “malaria transmission chain” by an integrated approach. Moreover, Italy was the first country to develop special legislation for the fight against malaria, representing an example of integration between scientific, political, social and economic knowledge. In 1970, after decades of fight, the World Health Organization officially declared Italy free from malaria.