Examples of Biological Small Angle Scattering

Abstract

In this chapter we illustrate the biological applications of small angle scattering. We cover examples of contrast matching has been used in the neutron case and with SAXS,. time-resolved studies that have helped reveal mechanism and how SAXS or SANS as a solution technique can access information missing from other studies, in particular residues that may be crystallographically undefined. We show examples of puting known structural information in context, and following large-scale functional changes or show when distinct populations co-exist in solution. The list of examples provided is not exhaustive and should be seen as a glimpse of the potential of biological mechanisms where SAXS or SANS can provide unique information complementary to other methods and help define function and mechanism.