Around the world, familiar ideological conflicts over the market are becoming increasingly territorialized in the form of policy conflicts between national and subnational governments. Thanks to a series of trends such as globalization, democratization, and especially decentralization, subnational governments are now in a position more effectively to challenge the ideological orientation of the national government. This book conceptualizes these challenges as operating in two related but distinct modes. The first stems from elected subnational officials who use their authority, resources, and legitimacy to design, implement, and defend subnational policy regimes that deviate ideologically from national policy regimes. The second occurs when these same officials use their authority, resources, and legitimacy to question, oppose, and alter the ideological content of national policy regimes. The book focuses on three similarly situated countries in Latin America where these two types of policy challenges met different fates; neither challenge succeeded in Peru, both succeeded in Bolivia, and Ecuador experienced an intermediate outcome marked by the success of the first type of challenge (that is, the defense of a deviant, neoliberal subnational policy regime) and the failure of the second (that is, the inability to alter a statist national policy regime). Derived from the in-depth study of these outcomes, the book’s theoretical argument emphasizes three causal variables: (1) the structural significance of the territory over which subnational elected officials preside, (2) the level of institutional capacity they can harness, and (3) the strength of the societal coalitions they can build both within and across subnational jurisdictions.