This book explores the word meaning as it is used in such expressions as “the meaning of life,” “the search for meaning,” “ultimate meaning.” In many of the metaphysical contexts where we find the word meaning, it appears to mean “purpose,” “value,” “goal,” “direction,” and even “God.” The book answers the following questions: How did the English word meaning come to carry these various sub-senses, given that its original sense has to do with signifying? When did the notion of a “meaning of life” arise in English and other languages? How does the English word meaning, which is a verbal noun, differ in these usages from the roughly equivalent words in other European languages? How did the word evolve in usage over time? How has it been used in recent decades? The book’s chapters show that the usage is relatively recent, arising in the late eighteenth century in German Romanticism and passing into English in the early nineteenth century; that the English word functions differently from the way its European near-equivalents do, thanks to its ability to suggest “signifying” and hence “interpretation”; that it is seldom defined and hence ambiguous and polyvalent; that it functions today in a wide variety of contexts, including psychotherapy and the continuing conversation between secularism and religion; and that ambiguity and polyvalence are actually the source of its power, since those qualities allow for flexibility in the way the word is understood.