This chapter examines Kant’s theory of the relation between God’s causal activity in the world and so-called “secondary” causation, the causality of created beings. The central question he faces here is the traditional one for a theistic metaphysics: How does the activity of God viewed as primordial creator and conserver of the world relate in general to the causal activity, if any, of created beings? His own evolving account of the divine causal role is shaped by his ongoing engagement with three competing theories of divine causation distinguished in late scholastic philosophy, and vigorously debated in the modern period by Malebranche and Leibniz. It is shown here that the most significant milestone in the emergence of Kant’s mature account does not lie in his transition from pre-Critical to Critical philosopher, but in an earlier one from necessitarian to libertarian on human agency.