In the medicine of the fifty years, the prevailing paradigms were the ‘biopsychosocial model’ and ‘evidence-based medicine’. The currently emerging vision is ‘personalized/precision medicine’. The two interchangeable names—personalized medicine and precision medicine—raise fundamental questions. Is increased precision an improvement in the personal aspects of care or does it risk an erosion of privacy? Do ‘precise’ and ‘personalized’ approaches marginalize public health? What are the roles of culture and society in the process of personalization? How can personalized medicine’s focus on the differences among individuals contribute to the global enterprise of health? In this project, scientists who are leading the revolution of personalized medicine are engaged with clinicians, ethicists, and experts in sociology of medicine and medical law in the search for a common language, elucidating and discussing the moral and social dimensions of personalized/precision medicine. The result is diverse layers of critical analysis and insights. The book contains eighteen chapters. The opening chapters map the horizon of the discourse, articulating the vision and practice of personalized medicine in the contexts of the history of ideas, philosophy of science, and global health. The subsequent chapters explicate specific topics: genetic newborn screening, rare diseases, disorders of consciousness, gender, the clinical encounter, public health, and CRISPR. The concluding chapters offer critical reflections by academic science and technology studies, and by religious traditions. The book concludes by presenting an up-to-date overview from the perspective of research and development.